Mechanistic investigation reveals ligand-controlled regiodivergent vinylcyclopropane rearrangement to distinct cyclopentenes, demonstrating reductive elimination determines product selectivity.
A ligand‐controlled regiodivergence in Ni‐catalyzed rearrangement of vinylcyclopropanes to 1,4‐ or 1,5‐disubstituted cyclopentenes is reported. The 1,4‐ or 1,5‐disubstituted cyclopentene is selectively obtained depending on the choice of ligands. Detailed kinetic studies and density functional theory calculations on the catalytic cycle revealed that the product selectivity is determined at the reductive elimination step from the six‐membered η 1 ‐allyl intermediate.
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Irifune et al. (2023) studied this question.
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