Population
Helical strips of dog renal arteries
Comparison
Angiotensin I and II administration, with and… vs Arteries with versus without endothelium…
Design
Preclinical
Authors
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Suggests incomplete vascular Ang II blockade by ACE inhibitors alone; hypothesis-generating for chymase-targeted therapies pending human studies.
This preclinical study demonstrates that Angiotensin I conversion to Angiotensin II in dog renal arteries involves both endothelial ACE and subendothelial chymostatin-sensitive enzymes.
Okamura et al. (1990) studied this question.
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