Key result
Loss of pacsin 2 function via siRNA results in loss of morphologically defined caveolae and accumulation of caveolin proteins within the plasma membrane.
Pacsin 2 is recruited to caveolae and plays an important role in the formation and morphogenesis of plasma membrane caveolae.
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Animal data implicate pacsin 2 in caveolae formation; human relevance and therapeutic potential remain untested.
Hansen et al. (2011) studied this question. pacsin 2 siRNA and overexpression was evaluated on caveolar biogenesis and morphogenesis. Loss of pacsin 2 function via siRNA results in loss of morphologically defined caveolae and accumulation of caveolin proteins within the plasma membrane.
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