Key result
Multiple endogenous protein kinases and phosphatases functionally couple to the BK channel complex to allow conditional modulation of BK channel activity in rat cerebellar Purkinje neurons.
Population
Dissociated rat cerebellar Purkinje neurons
Design
Preclinical
Authors
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Hypothesis-generating for native BK channel regulation in neurons; leaves open translation to human cerebellar function or disease.
Demonstrates that native neuronal BK channels are conditionally modulated by a complex of endogenous protein kinases and phosphatases.
H. Widmer (2003) studied this question. Protein kinases and phosphatases (PKA, PKC, PP1, PP2A) was evaluated on BK channel activity. Multiple endogenous protein kinases and phosphatases functionally couple to the BK channel complex to allow conditional modulation of BK channel activity in rat cerebellar Purkinje neurons.