Population
Rat brain and guinea pig cerebral cortex synaptosomes
Design
Preclinical
Authors
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Questions equivalence of binding and functional Ca2+ effects in neural tissue; leaves open in vivo relevance for channel modulators.
The study demonstrates a dissociation between the binding of the Ca2+ channel activator BAY K 8644 and its functional effects on calcium uptake in brain synaptosomes.
Rampe et al. (1984) studied this question.
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