What is the clinical evidence from this study?

Study design: Other. Population: Prostate cancer. Intervention: Thapsigargin (TG). Primary outcome: Apoptosis and store-operated Ca2+ current (Istore).

August 1, 2000The Journal of PhysiologyOpen Access

Store depletion and store‐operated Ca2+ current in human prostate cancer LNCaP cells: involvement in apoptosis

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Key result

In androgen-sensitive prostate cancer LNCaP cells, depletion of intracellular Ca2+ stores by thapsigargin triggers apoptosis without requiring the activation of store-operated Ca2+ current.

Population

Androgen-sensitive human prostate cancer LNCaP cells

Design

Preclinical

Authors

RSRoman SkrymaCentre National de la Recherche Scientifique PMPascal MariotInserm XBXuefen Le BourhisCentre National de la Recherche Scientifique

Discussion

Member takes

Overview

Hypothesis-generating for Ca2+ store depletion as an apoptosis trigger in prostate cancer independent of SOCE; requires in vivo validation before therapeutic exploration.

Structured PICO

Population

In vitro study using androgen-sensitive human prostate cancer LNCaP cells to investigate apoptosis mechanisms.

Intervention

Thapsigargin (TG) (0.1 microM)

Outcome

Induction of apoptosis and characterization of store-operated Ca2+ current (Istore)surrogate

Depletion of intracellular calcium stores triggers apoptosis in prostate cancer cells independently of store-operated calcium entry.

Cite This Study

Skryma et al. (2000) studied Prostate cancer. Thapsigargin (TG) was evaluated on Apoptosis and store-operated Ca2+ current (Istore). In androgen-sensitive prostate cancer LNCaP cells, depletion of intracellular Ca2+ stores by thapsigargin triggers apoptosis without requiring the activation of store-operated Ca2+ current.

synapsesocial.com/papers/6a86f9acbb0787ff27ca13cb https://doi.org/10.1111/j.1469-7793.2000.00071.x

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August 1, 2000The Journal of PhysiologyOpen Access

Store depletion and store‐operated Ca2+ current in human prostate cancer LNCaP cells: involvement in apoptosis

View Full Paper

Ask AI

Bookmark

Key result

In androgen-sensitive prostate cancer LNCaP cells, depletion of intracellular Ca2+ stores by thapsigargin triggers apoptosis without requiring the activation of store-operated Ca2+ current.

Population

Androgen-sensitive human prostate cancer LNCaP cells

Design

Preclinical

Authors

RSRoman SkrymaCentre National de la Recherche Scientifique PMPascal MariotInserm XBXuefen Le BourhisCentre National de la Recherche Scientifique

Discussion

Member takes

Overview

Hypothesis-generating for Ca2+ store depletion as an apoptosis trigger in prostate cancer independent of SOCE; requires in vivo validation before therapeutic exploration.

Structured PICO

Population

In vitro study using androgen-sensitive human prostate cancer LNCaP cells to investigate apoptosis mechanisms.

Intervention

Thapsigargin (TG) (0.1 microM)

Outcome

Induction of apoptosis and characterization of store-operated Ca2+ current (Istore)surrogate

Depletion of intracellular calcium stores triggers apoptosis in prostate cancer cells independently of store-operated calcium entry.

Cite This Study

synapsesocial.com/papers/6a86f9acbb0787ff27ca13cb https://doi.org/10.1111/j.1469-7793.2000.00071.x

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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