Key result
Normoglycemic patients had a significantly lower risk of all-cause mortality (RR 0.66) compared with prediabetic patients undergoing percutaneous coronary intervention.
Why the study?
The association between prediabetes and adverse clinical outcomes following PCI is inconsistent, unlike outcomes in patients with diabetes mellitus.
Does prediabetes increase all-cause mortality compared to normoglycaemia and diabetes mellitus in patients undergoing percutaneous coronary intervention?
Meta-Analysis (n=40,298)
Does prediabetes increase all-cause mortality compared to normoglycaemia and diabetes mellitus in patients undergoing percutaneous coronary intervention?
Relative Risk: 0.66 (95% CI 0.52–0.84)
p-value: p=0.0007
In patients undergoing PCI, prediabetes confers an intermediate risk of mortality and adverse cardiovascular events that is higher than normoglycaemia but lower than established diabetes mellitus.
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Prediabetes signals intermediate post-PCI mortality and MACE risk between normoglycemia and diabetes; confirms graded dysglycaemia impact for refined stratification.
Ahsan et al. (2023) conducted a meta-analysis in Coronary artery disease (n=40,298). Prediabetes vs. Normoglycaemia was evaluated on all-cause mortality (RR 0.66, 95% CI 0.52-0.84, p=0.0007). Normoglycemic patients had a significantly lower risk of all-cause mortality (RR 0.66) compared with prediabetic patients undergoing percutaneous coronary intervention.
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