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January 11, 2014AJP Heart and Circulatory Physiology

Aging significantly increased neointimal hyperplasia after vascular injury (N/NM ratio 0.8 vs 0.54, p=0.008), driven by macrophage-derived IL-18 and fibrinogen deposition.

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Why the study?

Does macrophage depletion with clodronate liposomes reduce neointimal hyperplasia and IL-18 accumulation after vascular injury in aged rats?

Population

Aged male Fisher rats (21- to 23-mo-old, F344) and young male Fisher rats (2-4 mo-old)

Comparison

Balloon injury in the right iliac artery… vs Young rats; control liposomes

Design

Preclinical, Investigator blinded to the experimental group for morphometric…

Follow-up

Up to 30 days

Key result

Aging significantly increased neointimal hyperplasia after vascular injury (N/NM ratio 0.8 vs 0.54, p=0.008), driven by macrophage-derived IL-18 and fibrinogen deposition.

Authors

LRLuis Rodriguez-MenocalMFMohd Hafeez FaridiLMLaisel Martinez

Discussion

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Overview

Aging heightens post-injury neointimal hyperplasia via macrophage IL-18 in rats; leaves open targeted inhibition for clinical restenosis prevention.

Structured PICO

Does macrophage depletion with clodronate liposomes reduce neointimal hyperplasia and IL-18 accumulation after vascular injury in aged rats?

P
Population
Male Fisher rats, either young (2-4 months) or aged (21-24 months), subjected to balloon injury in the right iliac artery to study age-related vascular remodeling.
E
Exposure
Balloon injury in the right iliac artery; systemic and local depletion of macrophages with intravenous clodronate liposomes (5 mg/kg)
C
Comparator
Young rats (for age comparison); control liposomes (for macrophage depletion comparison)
O
Outcome
Neointima to neointima-media thickness ratio (N/NM ratio) at 30 days post-injurysurrogate

Main Result

Absolute Event Rate: 0.8% vs 0.54%

p-value: p=0.008

Aging exacerbates post-injury neointimal hyperplasia through a local inflammatory response driven by macrophage-derived IL-18, which inhibits VSMC apoptosis and promotes further inflammation.

Limitations

  • Animal model may not fully replicate human vascular aging
  • No correction for multiple comparisons in microarray analysis

Cite This Study

Rodriguez-Menocal et al. (2014) studied Vascular injury and neointimal hyperplasia. Aging vs. Young rats was evaluated on Neointima to neointima-media thickness ratio (N/NM ratio) at day 30 (p=0.008). Aging significantly increased neointimal hyperplasia after vascular injury (N/NM ratio 0.8 vs 0.54, p=0.008), driven by macrophage-derived IL-18 and fibrinogen deposition.

synapsesocial.com/papers/6a86fc5ea810ea404bcf9b5chttps://doi.org/10.1152/ajpheart.00641.2013
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