Why the study?
Does SPECT imaging with 133-Xenon improve the detection of intracranial angioma compared to CT scan in patients with Sturge-Weber disease?
Does SPECT imaging with 133-Xenon improve the detection of intracranial angioma compared to CT scan in patients with Sturge-Weber disease?
SPECT imaging with 133-Xenon is a sensitive method for visualizing intracranial angioma in Sturge-Weber disease, providing diagnostic aid when CT scan is not reliable.
SPECT may aid angioma detection when CT is inconclusive in Sturge-Weber; leaves open need for prospective validation before clinical adoption.
Regional cerebral blood flow (rCBF) was studied using SPECT (single photon emission computed tomography) with 133-Xenon in 13 patients with confirmed Sturge-Weber disease, aged 9 months to 18 years. CT scan, performed at the same time, showed evident cerebral angioma in 10 but not in three. A marked hypoperfused area was found in all patients, ranging from -32% to -72% and of the same location as the CT signs. The hypoperfusion seems to result from post ictal phenomenon as well as from chronic ischaemia. SPECT imaging is therefore a sensitive method for visualising intracranial angioma in Sturge-Weber disease and it provides an aid for diagnosis when a CT scan is not reliable.
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Chiron et al. (1989) studied this question.
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