Key result
Higher atrial fibrillation symptom severity was associated with an increased risk of cardiovascular morbidity and mortality (HR 1.38; 95% CI 1.15-1.66; P=0.001).
Why the study?
Is higher symptom severity associated with increased cardiovascular morbidity and mortality in patients with permanent atrial fibrillation?
Population
558 patients with permanent atrial fibrillation from the RACE II study, mean age 68 ± 8 years.
Comparison
High symptom severity vs Low or moderate symptom severity
Design
Cohort
Follow-up
Median 3.0 (interquartile range 2.3-3.0) years
Authors
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May refine prognostication in permanent AF; hypothesis-generating for symptom-targeted interventions in trials.
Cohort (n=558)
Is higher symptom severity associated with increased cardiovascular morbidity and mortality in patients with permanent atrial fibrillation?
Hazard Ratio: 1.38 (95% CI 1.15–1.66)
Absolute Event Rate: 19% vs 9%
p-value: p=0.001
In patients with permanent atrial fibrillation, greater symptom severity is independently associated with a higher risk of cardiovascular morbidity and mortality, driven mainly by heart failure hospitalizations.
Vermond et al. (2014) conducted a cohort in Permanent atrial fibrillation (n=558). Higher atrial fibrillation symptom severity (AFSS score) vs. Lower atrial fibrillation symptom severity was evaluated on Composite of cardiovascular morbidity and mortality (HR 1.38, 95% CI 1.15-1.66, p=0.001). Higher atrial fibrillation symptom severity was associated with an increased risk of cardiovascular morbidity and mortality (HR 1.38; 95% CI 1.15-1.66; P=0.001).
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