Management of Seasonal Allergic Rhinitis: Comparative Efficacy of the Newer‐Generation Prescription Antihistamines

This is the authors' abstract. We don't add key points for this paper.

PURPOSE: To discuss the efficacy and safety of second-generation prescription antihistamines, cetirizine, desloratadine, and fexofenadine, and to inform nurse practitioners (NP) who are in a position to optimally manage patients presenting with seasonal allergic rhinitis (SAR). DATA SOURCES: Selected published clinical trials. CONCLUSIONS: NP, who are ideally placed to successfully manage the majority of patients with SAR, should be fully aware of the treatment options available. Although first-generation over-the-counter antihistamines are convenient to use and are readily accessible, patients run the risk of experiencing adverse effects, such as sedation. For this reason, second-generation antihistamines should be considered a better alternative; however, they need to be evaluated individually on the basis of their proven efficacy and safety. Both cetirizine and fexofenadine are equally effective at relieving the symptoms of SAR; however, cetirizine has been shown to be more likely to cause sedation and impairment. IMPLICATIONS FOR PRACTICE: If left untreated, SAR can have a substantial effect on patients' quality of life, resulting in fatigue, irritability, sleep disorders, and cognitive impairment.