Key result
Preoperative statin use did not significantly decrease the occurrence of atrial fibrillation following cardiac surgery compared to control (OR 0.85).
Why the study?
Does preoperative use of statins prevent postoperative atrial fibrillation in patients undergoing cardiac surgery?
Meta-Analysis (n=10,165)
Does preoperative use of statins prevent postoperative atrial fibrillation in patients undergoing cardiac surgery?
Odds Ratio: 0.85 (95% CI 0.66–1.09)
p-value: p=0.19
Preoperative statin therapy does not significantly reduce the occurrence of postoperative atrial fibrillation following cardiac surgery based on this meta-analysis of observational studies.
Does not support preoperative statins for postoperative AF prevention; leaves open whether RCTs would show benefit.
The preoperative medication of statins showed no significant decrease in AF occurrence following cardiac surgery in this Meta-analysis result. More prospective studies and researches are needed to explore and demonstrate the accurate mechanism and effect of statins on postoperative AF.
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Wang et al. (2010) conducted a meta-analysis in Postoperative atrial fibrillation following cardiac surgery (n=10,165). Preoperative statins vs. Control group (no statins) was evaluated on Atrial fibrillation occurrence following cardiac surgery (OR 0.85, 95% CI 0.66 to 1.09, p=0.19). Preoperative statin use did not significantly decrease the occurrence of atrial fibrillation following cardiac surgery compared to control (OR 0.85).
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