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April 1, 1922The Journal of Experimental MedicineOpen Access

Modification of an Improved Anaerobe Jar

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Population

Guinea pigs

Design

Preclinical

Authors

JBJ. Howard BrownEmory University Hospital Midtown

Discussion

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Implication

Does not guide typhus care in humans; leaves open non-living filterable agent as hypothesis needing validation.

Structured PICO

P
Population
Guinea pigs
I
Intervention
Filtrates of typhus-infected tissues
O
Outcome
Thermic reactions, lesions characteristic of experimental typhus, and immunity to later injections of active virus

Filtrates from typhus-infected tissues contain a non-living substance capable of inducing typhus-like reactions and immunity in guinea pigs.

Cite This Study

J. Howard Brown (1922) studied this question.

synapsesocial.com/papers/6a8702dcc026610cc182c8e6https://doi.org/10.1084/jem.35.4.467
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Anti-typhus vaccination of guineapigs with vaccine prepared from infected gerbils1942
  2. 2Fluorescent Antibody Methods in the Differentiation of Murine and Epidemic Typhus Sera; Specificity Changes Resulting from Previous Immunization1959 · 40 citations
  3. 3ACTIVE IMMUNIZATION OF GUINEA PIGS WITH THE VIRUS OF EQUINE ENCEPHALOMYELITIS1936 · 8 citations
  4. 4ANTITUBERCULOUS IMMUNITY IN MICE VACCINATED WITH KILLED TUBERCLE BACILLI1953 · 33 citations
  5. 5STUDIES ON THE INTERACTION BETWEEN PHAGOCYTES AND TUBERCLE BACILLI1957 · 62 citations