Key result
Lean subjects had 1125 genes more expressed and 1025 genes less expressed compared with metabolic syndrome subjects, with similar molecular adaptations in subcutaneous and visceral adipose tissue.
Population
32 women, categorized into four groups: lean, overweight, obese, and obese with metabolic syndrome…
Design
Cross-sectional
Authors
Loading...
Adipose gene expression changes with metabolic syndrome appear consistent across depots; hypothesis-generating for shared mechanisms and requires prospective validation.
Cross-Sectional (n=32)
No
Worsening adiposity and metabolic status are associated with similar molecular adaptations—specifically decreased metabolism and increased immune response—in both subcutaneous and visceral adipose tissue.
Klimčáková et al. (2010) conducted a cross-sectional in Obesity and metabolic syndrome (n=32). Obesity and metabolic syndrome vs. Lean status was evaluated on Gene expression profiling in subcutaneous and visceral adipose tissue. Lean subjects had 1125 genes more expressed and 1025 genes less expressed compared with metabolic syndrome subjects, with similar molecular adaptations in subcutaneous and visceral adipose tissue.