Skin Transplantation in the Foetal Lamb

Skin autografts and homo grafts have been performed in foetal lambs between the ages of 80 and 117 days. By means of histological examination following grafting, visual and histological examinations after birth, and by the use of second-set homo grafts, it was stablished that homo grafts are actively rejected by the foetus. This rejection gave every indication of belonging to the general class of activity acquired immune responses and in all respects confirmed at the foetal stage the observations of Medewar (1944, 1945) on young and adult animals.