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March 2, 1970JAMA

Genetic Markers in Human Blood

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Authors

JMJohn B. MialeUniversity of North Carolina at Chapel Hill

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Implication

Expert review evaluates genetically determined blood proteins and enzyme polymorphisms in human blood, highlighting nomenclature challenges in complex blood group systems.

Key Points

  • To review and evaluate reference texts compiling genetically determined human blood proteins, enzyme polymorphisms, and red cell antigen systems.
  • Comparative critical appraisal of major reference texts on human blood and serum groups, including Eloise Giblett's compendium.
  • Evaluation of comprehensive scientific chapters covering polymorphic serum proteins, red cell enzymes, and blood group genetic models.
  • Giblett's compendium offers detailed, scholarly reference material on haptoglobin, immunoglobulins, transferrin, beta-lipoprotein allotypes, pseudocholinesterase, alkaline phosphatase, and hemoglobins.
  • The text shows analytical limitations in its presentation of red cell antigen systems, specifically framing the debate between the Race-Sanger and Wiener genetic concepts.

Cite This Study

John B. Miale (1970) studied this question.

synapsesocial.com/papers/6a870634713eb98b40ca20bchttps://doi.org/10.1001/jama.1970.03170090063023
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