Key result
The Capillarys 3 Tera instrument demonstrated strong linear correlation (R2 = 0.996) and good precision compared to the Roche Tina-Quant HbA1c assay for routine venous samples.
Why the study?
Does the Capillarys 3 Tera instrument provide accurate and precise HbA1c measurements compared to the Roche c6000 instrument in routine venous samples?
Does the Capillarys 3 Tera instrument provide accurate and precise HbA1c measurements compared to the Roche c6000 instrument in routine venous samples?
Effect estimate: R2 = 0.996
The Capillarys 3 Tera instrument provides high-throughput, precise HbA1c testing with strong agreement to established immunological methods.
May offer high-throughput HbA1c testing; leaves open prospective validation for clinical use.
Hemoglobin A1c (HbA1c) is a frequently requested laboratory test and there is thus a need for high throughput instruments for this assay. We evaluated a new automated multicapillary zone electrophoresis instrument (Capillarys 3 Tera, Sebia, Lisses, France) for analysis of HbA1c in venous samples. Routine requested HbA1c samples were analyzed immunologically on a Roche c6000 instrument (n = 142) and then with the Capillarys 3 Tera instrument. The Capillarys 3 Tera instrument performed approximately 70 HbA1c tests/hour. There was a strong linear correlation between Capillarys 3 Tera and Roche Tina-Quant HbA1c Gen 3 assay (y = 1.003x – 0.3246 R2 = .996). The total CV for the 12 capillaries varied between 0.8 and 2.2% and there was a good agreement between duplicate samples (R2 = .997). In conclusion, the Capillarys 3 Tera instrument has a high assay capacity for HbA1c. It has a good precision and agreement with the Roche Tina-Quant HbA1c method and is well suited for high volume testing of HbA1c.
No takes yet. Share an insight, caveat, or question.
Rollborn et al. (2016) studied HbA1c testing (n=142). Capillarys 3 Tera instrument vs. Roche c6000 instrument was evaluated on Linear correlation between Capillarys 3 Tera and Roche Tina-Quant HbA1c Gen 3 assay (R2 = 0.996). The Capillarys 3 Tera instrument demonstrated strong linear correlation (R2 = 0.996) and good precision compared to the Roche Tina-Quant HbA1c assay for routine venous samples.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: