In 1927 Aschheim & Zondek discovered a gonadotrophic factor in the urine and serum of pregnant women. The presence of this hormone was detected by its ability to produce “blood points” and corpora lutea in the ovaries of immature rodents. In rabbits it caused ovulation and formation of corpora lutea (Friedman, 1929). Extension of this work (Evans & Simpson, 1929, Philipp, 1930, Collip, Thomson, McPhail & Williamson, 1931, Collip, 1931, Evans, Meyer & Simpson, 1932, Fluhman, 1932, Hamburger, 1933) soon led to the realization that this factor is different from all the known pituitary hormones.
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E. Diczfalusy (1953) studied this question.