September 1, 1998The Journal of Clinical Endocrinology & Metabolism

Acute Cardiovascular Effects of Insulin-Like Growth Factor I in Patients with Chronic Heart Failure1

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Why the study?

Does recombinant human IGF-I improve acute hemodynamics in patients with chronic heart failure?

Population

8 patients with chronic heart failure

Comparison

Recombinant human IGF-I i.v. over 4 h vs Placebo i.v. over 4 h

Design

RCT, randomized, double blind

Follow-up

7 h

Authors

MDMarc Y. DonathUniversity of Basel GSGabor SütschUniversity of Zurich BPBruno PivaUniversidade Federal de Sergipe

Discussion

Member takes

Implication

Acute IGF-I improves hemodynamics in chronic HF; extends prior data to RCT evidence and supports longer-term outcome trials.

Structured PICO

Does recombinant human IGF-I improve acute hemodynamics in patients with chronic heart failure?

Population

8 patients with chronic heart failure

Intervention

Recombinant human IGF-I (60 micrograms/kg) i.v. over 4 h

Comparator

Placebo i.v. over 4 h

Outcome

Acute hemodynamic effects (cardiac index, stroke volume index, systemic vascular resistance, right atrial pressure, pulmonary artery wedge pressure) monitored over 7 hsurrogate

Acute administration of IGF-I in patients with chronic heart failure safely improves cardiac performance by afterload reduction and possibly positive inotropic effects.

Cite This Study

Donath et al. (1998) studied this question.

synapsesocial.com/papers/6a870c5fb712452940cbb37f https://doi.org/10.1210/jcem.83.9.5122

Topics

Women and heart disease

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