Key result
In patients with functional mitral regurgitation, early mitral valve surgery or intervention was independently associated with lower event rates during follow-up (0.177; 95% CI 0.027-0.643; P=0.025).
Why the study?
Mitral regurgitation severity varies with haemodynamic conditions, making exercise testing important to evaluate its clinical relevance in degenerative and functional mitral regurgitation.
Does isometric handgrip exercise echocardiography identify clinically relevant dynamic changes in mitral regurgitation and predict outcomes in patients with at least mild MR?
Cohort (n=367)
Does isometric handgrip exercise echocardiography identify clinically relevant dynamic changes in mitral regurgitation and predict outcomes in patients with at least mild MR?
Effect estimate: 0.177 (95% CI 0.027-0.643)
p-value: p=0.025
Handgrip exercise echocardiography unmasks dynamic worsening of mitral regurgitation and identifies patients with functional MR who may benefit from early surgical or percutaneous intervention.
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May inform risk stratification in DegMR and FMR; leaves open whether exercise echocardiography should guide management.
Spieker et al. (2023) conducted a cohort in Degenerative and functional mitral regurgitation (n=367). Early mitral valve surgery/intervention vs. No early surgery/intervention was evaluated on Event rates during follow-up (0.177, 95% CI 0.027-0.643, p=0.025). In patients with functional mitral regurgitation, early mitral valve surgery or intervention was independently associated with lower event rates during follow-up (0.177; 95% CI 0.027-0.643; P=0.025).
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