Why the study?
Do calcium antagonists (nifedipine and perhexiline) reduce angina episodes and prevent ergonovine-induced spasm in patients with variant angina?
Population
10 consecutive hospitalized patients with uncontrolled variant angina
Comparison
Nifedipine 20 mg every 6 hours and perhexiline… vs Control period without treatment other than…
Design
Case_series
Follow-up
Short-term (days)
Authors
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May support nifedipine for variant angina symptoms; case-report data leave efficacy open for randomized confirmation.
Do calcium antagonists (nifedipine and perhexiline) reduce angina episodes and prevent ergonovine-induced spasm in patients with variant angina?
Nifedipine rapidly and effectively controls acute clinical manifestations of variant angina and prevents ergonovine-induced spasm, whereas perhexiline was ineffective in this small cohort.
Théroux et al. (1979) studied this question.
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