Why the study?
Does the type of suture material affect tumour cell adherence at sites of colonic injury in a rat model?
Does the type of suture material affect tumour cell adherence at sites of colonic injury in a rat model?
In a rat model, colotomy repair with silk, but not Prolene, significantly increased tumour cell adherence, suggesting suture material choice may be important in colorectal cancer surgery.
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Hypothesis-generating for suture effects on tumor adherence; does not support practice change in colorectal cancer surgery.
In an experimental animal model, radiolabelled viable intraperitoneal adenocarcinoma cells adhered in similar numbers to normal rat colon and that injured by a 1-cm colotomy, with median cell counts of 7002 and 8602 respectively (P not significant). Repair of the colotomy with interrupted silk resulted in a significant increase in the median number of cells adhering to the injury site (21,888; P = 0.0001 versus normal colon). Repair with Prolene had no effect on tumour cell adherence (a median of 7449 cells adhered; P not significant versus normal colon). Tumour cell adherence at sites of colonic injury is dependent on the suture material used and not on the injury itself in this model. This may be important when choosing suture type for anastomosis in patients undergoing surgery for colorectal cancer.
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Reinbach et al. (1993) studied this question.
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