Key result
An elevated LDL-C/HDL-C ratio (highest vs lowest quartile) was associated with an increased risk of new-onset diabetes in Chinese adults (HR 1.92; 95% CI 1.43-2.59; P for trend <0.001).
Why the study?
Although LDL-C/HDL-C ratio is a recognized marker for insulin resistance and cardiovascular disease, its association with diabetes risk has rarely been reported.
Does an elevated LDL-C/HDL-C ratio increase the risk of new-onset diabetes in adults without baseline diabetes?
Population
116,661 adults without baseline diabetes in China
Comparison
Higher LDL-C/HDL-C ratio quartiles vs the lowest quartile
Design
Retrospective cohort study
Follow-up
Median 2.98 years
Authors
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LDL-C/HDL-C ratio may predict new-onset diabetes risk; leaves open its added value beyond standard markers in validation studies.
Cohort (n=116,661)
Does an elevated LDL-C/HDL-C ratio increase the risk of new-onset diabetes in adults without baseline diabetes?
Hazard Ratio: 1.92 (95% CI 1.43–2.59)
Absolute Event Rate: 0.88% vs 0.31%
p-value: p=<0.001
An elevated LDL-C/HDL-C ratio is an independent risk factor for new-onset diabetes in Chinese adults.
Wei et al. (2020) conducted a cohort in diabetes (n=116,661). Elevated LDL-C/HDL-C ratio vs. Lowest quartile of LDL-C/HDL-C ratio was evaluated on new-onset diabetes (HR 1.92, 95% CI 1.43-2.59, p=<0.001). An elevated LDL-C/HDL-C ratio (highest vs lowest quartile) was associated with an increased risk of new-onset diabetes in Chinese adults (HR 1.92; 95% CI 1.43-2.59; P for trend <0.001).
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