Key result
Higher LDL/HDL ratio is linked to ~3-fold greater odds of sarcopenia in older adults.
Why the study?
Research examining how serum lipid levels relate to sarcopenia remains scarce, prompting this investigation into the association between the LDL/HDL ratio and sarcopenia in older adults.
Does a higher LDL/HDL ratio associate with an increased risk of sarcopenia in community-dwelling older adults?
Cross-Sectional (n=3,968)
Yes
Does a higher LDL/HDL ratio associate with an increased risk of sarcopenia in community-dwelling older adults?
Odds Ratio: 3.01 (95% CI 2.66–3.41)
p-value: p=<0.001
The LDL/HDL ratio is independently and positively associated with the risk of sarcopenia in community-dwelling older Chinese adults, outperforming individual lipid components in predictive ability.
Higher LDL/HDL ratio was associated with sarcopenia; leaves open causal role or preventive value in older adults.
OBJECTIVES: The link between lipid disorders and diverse diseases is amply documented. Yet, research probing how serum lipid levels tie in with sarcopenia remains scarce. This study delves into the connection between the LDL/HDL ratio and sarcopenia among elderly Chinese people. METHODS: A total of 3,968 senior participants from Chinese communities were included in this cross-sectional study. To explore the relationship between the LDL/HDL ratio and sarcopenia, both a multivariate logistic regression model and a restricted cubic spline model were used. ROC curve analysis was employed to gauge how well the LDL/HDL ratio can detect sarcopenia. RESULTS: Among the participants, 780 were diagnosed with sarcopenia. Multivariable logistic regression unveiled a significant positive correlation between the LDL/HDL ratio and sarcopenia. After adjusting for potential confounders, each unit increase in the LDL/HDL ratio corresponded to an approximately 3-fold higher odds of sarcopenia (OR = 3.01, 95% CI: 2.66-3.41, P < 0.001). A non - linear relationship between the LDL/HDL ratio and sarcopenia was confirmed by RSC analysis (P < 0.001). ROC curve analysis showed that the LDL/HDL ratio outperformed its individual components in predictive ability for sarcopenia. CONCLUSIONS: This study indicates that the LDL/HDL ratio may serve as an independent risk factor for sarcopenia.
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Wu et al. (2025) conducted a cross-sectional in Sarcopenia (n=3,968). LDL/HDL ratio vs. Lower LDL/HDL ratio was evaluated on Odds of sarcopenia per unit increase in LDL/HDL ratio (OR 3.01, 95% CI 2.66-3.41, p=<0.001). Each unit increase in the LDL/HDL ratio was associated with a 3-fold higher odds of sarcopenia (OR 3.01) in Chinese community-dwelling older adults.
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