Correlations of Serum Uric Acid and Lipid Concentrations in Normal, Gouty, and Atherosclerotic Men

Article1 May 1967Correlations of Serum Uric Acid and Lipid Concentrations in Normal, Gouty, and Atherosclerotic MenTHOMAS G. BENEDEK, M.D.THOMAS G. BENEDEK, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-851 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe existence of a correlation between gout and obesity has been accepted since ancient times, the alleged common denominator being gluttony. The validity of this belief has not been adequately tested and has been questioned (1). Despite the long-appreciated associations between obesity and atherosclerosis, studies of relationships between hyperuricemia, with or without clinical gout, and atherosclerosis have been undertaken only in recent years. The first systematic investigation of this kind was published by Gertler, Garn, and Levine (2) in 1951. These investigators found hyperuricemia to be present 4 times as frequently in a group of 92 men who had suffered...References1. TALBOTT JH: Gout, 2nd ed. Grune & Stratton, Inc., New York, 1964, pp. 145-146. Google Scholar2. GERTLERGARNLEVINE MMSMSA: Serum uric acid in relation to age and physique in health and in coronary artery disease. Ann. Intern. Med. 34: 1421, 1951. LinkGoogle Scholar3. KRAMERPERILSTEINDEMADEIROS DWPKA: Metabolic influences in vascular disorders with particular reference to cholesterol determinations in comparison with uric acid levels. Angiology 9: 162, 1958. CrossrefMedlineGoogle Scholar4. EIDLITZ M: Uric acid and arteriosclerosis. Lancet 2: 1046, 1961. CrossrefGoogle Scholar5. KOHNPROZAN PMGB: Hyperuricemia—relationship to hypercholesteremia and acute myocardial infarction. JAMA 170: 1909, 1959. CrossrefMedlineGoogle Scholar6. MEYERKYPROSGILROY JSGPJ: Hyperuricemia, gout and cerebrovascular disease. W. Virginia Med. J. 60: 150, 1964. MedlineGoogle Scholar7. HANSEN OE: Acute gouty arthritis provoked by cerebrovascular disease. Acta Med. Scand. 178: 423, 1965. CrossrefMedlineGoogle Scholar8. KINSEYWALTHERSISEWHITELAWSMITHWICK DRHSGR: Incidence of hyperuricemia in 400 hypertensive patients (abstract). Circulation 24: 972, 1961. Google Scholar9. WEISSSEGALOFFMOORE TEAC: Gout and diabetes. Metabolism 6: 103, 1957. MedlineGoogle Scholar10. HERMAN JB: Gout and diabetes. Metabolism 7: 703, 1958. MedlineGoogle Scholar11. BARTELSBALODIMOSCORN ECMCLR: The association of gout and diabetes mellitus. Med. Clin. N. Amer. 44: 433, 1960. CrossrefMedlineGoogle Scholar12. BECKETTLEWIS AGJG: Gout and the serum uric acid in diabetes mellitus. Quart. J. Med. 29: 443, 1960. MedlineGoogle Scholar13. WHITEHOUSECLEARY FWWJ: Diabetes mellitus in patients with gout. JAMA 197: 73, 1966. CrossrefMedlineGoogle Scholar14. HARRIS-JONES JN: Hyperuricemia and essential hypcrcholestciolacmia. Lancet 1: 857, 1957. CrossrefGoogle Scholar15. JENSENBLANKENHORNKORNERUP JDHV: Blood-uric-acid levels in familial hypercholesterolaemia. Lancet 1: 298, 1966. CrossrefMedlineGoogle Scholar16. ALBRINK MJ: Triglycerides, lipoproteins, and coronary artery disease. Arch. Intern. Med. (Chicago) 109: 345, 1962. CrossrefMedlineGoogle Scholar17. BROWNHESLINDOYLE DFASJT: Fasting and postprandial serum triglyceride levels in healthy young Americans. Amer. J. Clin. Nutr. 13: 1, 1963. CrossrefMedlineGoogle Scholar18. SCHAEFER LE: Serum cholesterol-triglyceride distribution in a "normal" New York City population. Amer. J. Med. 36: 262, 1964. CrossrefMedlineGoogle Scholar19. DUNNMOSES JPC: Correlation of serum lipids with uric acid and blood sugar in normal males. Metabolism 14: 788, 1965. CrossrefMedlineGoogle Scholar20. ALBRINKMEIGSMAN MJJWEB: Serum lipids, hypertension and coronary artery disease. Amer. J. Med. 31: 4, 1961. CrossrefMedlineGoogle Scholar21. BROWNKINCHDOYLE DFSHJT: Serum triglycerides in health and in ischemic heart disease. New Eng. J. Med. 273: 947, 1965. CrossrefMedlineGoogle Scholar22. ALBRINKMEIGSGRANOFF MJJWMA: Weight gain and serum triglycerides in normal men. New Eng. J. Med. 266: 484, 1962. CrossrefMedlineGoogle Scholar23. ADLERSBERGSCHAEFERSTEINBERGWANG DLEAGC: Age, sex, serum lipids, and coronary atherosclerosis. JAMA 162: 619, 1956. CrossrefMedlineGoogle Scholar24. SCHILLINGCHRISTAKISBENNETTCOYLE FJGJNJJF: Studies of serum cholesterol in 4,244 men and women: an epidemiological and pathogenetic interpretation. Amer. J. Public Health 54: 461, 1964. CrossrefGoogle Scholar25. JOHNSONEPSTEINKJELSBERG BCFHMO: Distributions and familial studies of blood pressure and serum cholesterol levels in a total community—Tecumseh, Michigan. J. Chronic Dis. 18: 147, 1965. CrossrefMedlineGoogle Scholar26. MIKKELSENDODGEVALKENBURG WMHJH: The distribution of serum uric acid values in a population unselected as to gout or hyperuricemia: Tecumseh, Michigan 1959-1960. Amer. J. Med. 39: 242, 1965. CrossrefMedlineGoogle Scholar27. HAUGEHARVALD MB: Heredity in gout and hyperuricemia. Acta Med. Scand. 152: 247, 1955. CrossrefMedlineGoogle Scholar28. SCHOENFELDGOLDBERGER MRE: Serum cholesterol—uric acid correlations. Metabolism 12: 714, 1963. MedlineGoogle Scholar29. KUZELLGLOVERGIBBSBLAU WCRPJORA: Effect of sulfinpyrazone on total serum cholesterol in gout: a long-term study. Amer. J. Med. Sci. 248: 164, 1964. CrossrefMedlineGoogle Scholar30. BERKOWITZ D: Blood lipid and uric acid interrelationships. JAMA 190: 856, 1964. CrossrefMedlineGoogle Scholar31. FELDMANWALLACE EBSL: Hypertriglyceridemia in gout. Circulation 29 (suppl.): 508, 1964. CrossrefGoogle Scholar32. PRAETORIUSPOULSEN EH: Enzymatic determination of uric acid, with detailed directions. Scand. J. Clin. Lab. Invest. 3: 273, 1953. CrossrefGoogle Scholar33. SPERRYWEBB WMM: A revision of the Schoenheimer-Sperry method for cholesterol determination. J. Biol. Chem. 187: 97, 1950. CrossrefMedlineGoogle Scholar34. VANHANDELZILVERSMIT EDB: Micromethod for the direct determination of serum triglycerides. J. Lab. Clin. Med. 50: 152, 1957. MedlineGoogle Scholar35. TERRISBLATT MS: Differences in serum cholesterol in young white and Negro adults. Amer. J. Public Health 54: 1996, 1964. CrossrefGoogle Scholar36. DANOWSKITINSMANMOSES TSCAC: Hydrocortisone and/or desiccated thyroid in physiologic dosage. VIII. Lipid and body fluid patterns in North American Negro and white prisoners. Metabolism 12: 117, 1963. MedlineGoogle Scholar37. SIEGEL S: Nonparametric Statistics for the Behavioral Sciences. McGraw-Hill Book Co., Inc., New York, 1956, pp. 223-229. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Pittsburgh, PennsylvaniaFrom the Veterans Administration Hospital and the Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pa.Requests for reprints should be addressed to Thomas G. Benedek, M.D., VA Hospital, University Dr., Pittsburgh, Pa. 15240. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByComprehensive laboratory reference intervals for routine biochemical markers and pro‐oxidant‐antioxidant balance (PAB) in male adultsAssociation between serum uric acid and cardiovascular risk in nonhypertensive and nondiabetic individuals: The Taiwan I-Lan Longitudinal Aging StudyClinical Aspects of Gout and Associated Disease StatesSignificant interaction between LRP2 rs2544390 in intron 1 and alcohol drinking for serum uric acid levels among a Japanese populationSerum uric acid distribution according to SLC22A12 W258X genotype in a cross-sectional study of a general Japanese populationSignificant association of serum uric acid levels with SLC2A9 rs11722228 among a Japanese populationAcute myocardial infarction associated with acute gouty arthritisGout and coronary artery disease: Epidemiologic cluesGout and the risk of acute myocardial infarctionThe Relation of Postmenopausal Hormone Therapy to Serum Uric Acid and the Risk of Coronary Heart Disease Events: The Heart and Estrogen–Progestin Replacement Study (HERS)GouttePossible interactions of the endothelial constitutive nitric oxide synthase genotype with alcohol drinking and walking time for high serum uric acid levels among JapaneseAssociation of a 27-bp repeat polymorphism in intron 4 of endothelial constitutive nitric oxide synthase gene with serum uric acid levels in chinese subjects with type 2 diabetesGotaUric acid is closely linked to vascular nitric oxide activitySerum Uric Acid and Risk of Coronary Heart DiseaseSerum carotenoids and uric acid levels in relation to cancerCorrelates of uric acid and its association with asymptomatic carotid atherosclerosis: The ARIC studyHigh uric acid: A metabolic marker of coronary heart disease among alcohol abstainers?The determinants and prognostic significance of serum uric acid in elderly patients of the European Working Party on High Blood Pressure in the Elderly TrialHyperlipidémies et manifestations ostéoarticulairesGout and coronary heart disease: The framingham studyHyperuricemia and hypertriglyceridemia: Metabolic basis for the associationHDL-Cholesterol Levels in Gouty PatientsMusculoskeletal disorders in patients with hyperlipidaemia.Serum uric acid and coronary heart diseaseHyperuricaemia and atherosclerosisSelected Physiologic and Drug Effects on Serum Uric Acid Levels in an Elderly PopulationFurosemide-induced hyperuricemia, hyperglycemia, hypertension and arterial lesions in nonarteriosclerotic and arteriosclerotic ratsFactors influencing the serum uric acid level. A study based on a population survey in Hisayama town, Kyushu, JapanUric acid: a risk factor for coronary heart disease?Hyperlipidemia in primary goutZum Einfluß einer Hochfettdiät auf den Serumharnsäurespiegel bei RattenAbnormal Urate Excretion Associated with Renal and Systemic Disorders, Drugs, and ToxinsEffect of increased serum urate levels on virgin rats with no arteriosclerosis versus breeder rats with preexistent arteriosclerosisObesity and HyperuricaemiaEpidemiology of serum uric acid among 8000 Japanese-American men in HawaiiAngina Pectoris and Myocardial InfarctionThe Epidemiology of Hyperuricemia and GoutThe Etiology and Pathogenesis of GoutKlinische Wertigkeit der Hyperuricämie. Beziehung zu anderen KrankheitenVerlauf der GichtThe Ecology of Normal Values in Clinical ChemistryGout and hypertensionHyperuricemia in coronary, cerebral and peripheral arterial disease: An explanationHarns�urekonzentration im Serum bei verschiedenen Hyperlipoprotein�mie-Typen, Herzinfarkt und GichtUric acid kinetic studies in the immediate post-myocardial-infarction periodDisorders of the Locomotor System associated with Abnormalities of Lipid Metabolism and the LipoidosesSERUM URIC ACID LEVELS IN WOMENLIST OF REFERENCESReferencesÜber die Bedeutung der Hyperurikämie bei chronischer arterieller Verschlußkrankheit und bei postthrombotischem SyndromPlasma lipoproteins, glucose tolerance and insulin response in primary goutHyperuricemia in Health and DiseaseTriglyceride concentrations in primary gout and gout of chronic lead nephropathyNineteenth rheumatism review. Part-IIIReferencesReduction of serum uric acid in young men during physical trainingHypoxanthine-Guanine Phosphoribosyltransferase Deficiency in GoutWILLIAM N. KELLEY, M.D., MARTIN L. GREENE, M.D., FREDERICK M. ROSENBLOOM, M.D., J. FRANK HENDERSON, PH.D., J. E. SEEGMILLER, M.D.The relationship of serum uric acid to risk factors in coronary heart diseaseAlterations of Factors Predisposing to Coronary Heart DiseaseLEON D. OSTRANDER JR., M.D., F.A.C.P.FAMILIAL PLASMA CHOLESTEROL ESTER DEFICIENCYChapter 17. Atherosclerosis 1 May 1967Volume 66, Issue 5Page: 851-861KeywordsAtherosclerosisAttentionCholesterolGoutHospital medicineLipidsObesityResearch laboratoriesThrombosisUric acid Issue Published: 1 May 1967 PDF DownloadLoading ...