This review discusses the dose-response relationship for radiotherapy and chemotherapy in clinical oncology.
May guide dosing in Hodgkin's disease, leukemia, and breast cancer; extends historical observations but leaves prospective validation open.
The relationship of dose (and dose rate) to response and toxicity in clinical oncology is reviewed. The concepts expressed by some authors in dose-response studies in animal and human systems are reviewed briefly. Dose rate and tactics of conducting clinical studies are reviewed for both radiotherapy and various types of chemotherapeutic treatment. Examples are given from clinical studies in Hodgkin's disease, acute leukemia, and breast cancer that may prove useful in planning future clinical studies.
No takes yet. Share an insight, caveat, or question.
E. A. Gehan (1984) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: