November 1, 1979Annals of Internal Medicine
Risk Factors for Doxorubicin-lnduced Congestive Heart Failure
Why the study?
What are the risk factors (cumulative dose, dosing schedule, age) for developing doxorubicin-induced congestive heart failure in patients receiving doxorubicin?
Population
4,018 patients receiving doxorubicin (retrospective analysis of patient records)
Comparison
Doxorubicin administration vs Different dosing schedules and lower cumulative…
Design
Cohort
Authors
Discussion
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Implication
The risk of doxorubicin-induced congestive heart failure is dose-dependent, increases with age, and can be mitigated by using a weekly rather than an every 3-week dosing schedule.
Structured PICO
What are the risk factors (cumulative dose, dosing schedule, age) for developing doxorubicin-induced congestive heart failure in patients receiving doxorubicin?
P
Population
4,018 patients receiving doxorubicin (retrospective analysis of patient records)
I
Intervention
Doxorubicin administration (evaluating cumulative dose, weekly dosing schedule, and patient age)
C
Comparator
Different dosing schedules (every 3-week schedule) and lower cumulative doses
O
Outcome
Development of doxorubicin-induced congestive heart failuresafety
The risk of doxorubicin-induced congestive heart failure is dose-dependent, increases with age, and can be mitigated by using a weekly rather than an every 3-week dosing schedule.
Cite This Study
Daniel D. Von Hoff (1979) studied this question.