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September 15, 1985Cancer

Doxorubicin-induced congestive heart failure in adults

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Why the study?

Does standard therapy with digitalis and diuretics improve the clinical course and survival in adults with doxorubicin-induced congestive heart failure?

Population

43 adult patients with doxorubicin-induced congestive heart failure, median age 55 years, majority with a…

Design

Cohort

Authors

MHMohamed M. HaqUniversity of HoustonSLSewa S. LeghaThe University of Texas MD Anderson Cancer CenterJCJ. K. ChoksiUniversity of North Carolina at Chapel Hill

Discussion

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Implication

May support digitalis and diuretics in doxorubicin-induced CHF; leaves open randomized confirmation of survival benefit.

Structured PICO

Does standard therapy with digitalis and diuretics improve the clinical course and survival in adults with doxorubicin-induced congestive heart failure?

P
Population
43 adult patients with doxorubicin-induced congestive heart failure (CHF), median age 55 years (range 23-69), majority with a diagnosis of breast cancer.
I
Intervention
Standard therapy with digitalis and diuretics
O
Outcome
Clinical course, survival, and control of CHFhard clinical

Contrary to reports of a universally poor prognosis, doxorubicin-induced congestive heart failure is frequently treatable and can be controlled in a majority of patients using standard therapy with digitalis and diuretics.

Cite This Study

Haq et al. (1985) studied this question.

synapsesocial.com/papers/6a73dcd0c1c8cbdb1d8de949https://doi.org/10.1002/1097-0142(19850915)56:6<1361::aid-cncr2820560624>3.0.co;2-s

Topics

Heart failureHFrEF treatment
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A clinicopathologic analysis of adriamycin cardiotoxicity1973 · 1,565 citations
  2. 2Congestive heart failure due to adriamycin cardiotoxicity: Its natural history in children1981 · 114 citations
  3. 3Risk Factors for Doxorubicin-lnduced Congestive Heart Failure1979 · 2,439 citations
  4. 4Reduction of Doxorubicin Cardiotoxicity by Prolonged Continuous Intravenous Infusion1982 · 768 citations
  5. 5Doxorubicin cardiotoxicity: possible role of digoxin in its prevention.1977 · 40 citations