Key result
Combination chemotherapy with liposomal doxorubicin and paclitaxel achieved a complete response in a 51-year-old man with recurrent adrenal epithelioid angiosarcoma.
Why the study?
Primary adrenal epithelioid angiosarcoma is extremely rare with a poor prognosis, and treatment options have not been well-studied.
Does combination chemotherapy with liposomal doxorubicin and paclitaxel improve tumor response in a patient with recurrent adrenal epithelioid angiosarcoma?
Case Report (n=1)
Does combination chemotherapy with liposomal doxorubicin and paclitaxel improve tumor response in a patient with recurrent adrenal epithelioid angiosarcoma?
Combination chemotherapy with liposomal doxorubicin and paclitaxel may be an effective treatment option for recurrent or advanced adrenal epithelioid angiosarcoma.
May offer a chemotherapy option in recurrent adrenal angiosarcoma; leaves open efficacy and survival data in larger cohorts.
BACKGROUND: Primary adrenal epithelioid angiosarcoma is an extremely rare cancer with a poor prognosis. Because of the rarity of this disease, treatment options have not been well-studied. CASE PRESENTATION: A 51-year-old man was admitted to Zhejiang Cancer Hospital, diagnosed with a recurrence of adrenal epithelioid angiosarcoma. He had undergone a surgical resection seven months earlier. Combination chemotherapy with liposomal doxorubicin and paclitaxel was administered. After two cycles of chemotherapy, his pain was relieved. Computed tomography (CT) suggested that the soft tissue tumour lesions in the surgical area had disappeared, mediastinal and mediastinal-hilar lymph nodes were significantly reduced or had disappeared, and the patient had achieved a partial response (PR). CT after six cycles of chemotherapy indicated that the patient had achieved a complete response (CR). CONCLUSION: Combination chemotherapy with liposomal doxorubicin and paclitaxel may be a preferred therapy for recurrent or advanced adrenal epithelioid angiosarcoma.
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Wei et al. (2021) conducted a case report in Postoperative recurrence of adrenal epithelioid angiosarcoma (n=1). Combination chemotherapy with liposomal doxorubicin and paclitaxel was evaluated on Tumor response. Combination chemotherapy with liposomal doxorubicin and paclitaxel achieved a complete response in a 51-year-old man with recurrent adrenal epithelioid angiosarcoma.
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