Key result
Cognitive behavior therapy significantly reduced PHQ-9 depression scores (mean reduction 7.74 vs 5.59, p=0.002) and improved mental health-related quality of life compared to treatment as usual in patients with atrial fibrillation.
Why the study?
Atrial fibrillation patients with depression experience markedly reduced quality of life, but the efficacy of cognitive behavior therapy on health-related quality of life required evaluation.
Does cognitive behavior therapy improve depression symptoms, illness perception, and quality of life in patients with atrial fibrillation and depression?
RCT (n=90)
Single-blind
1:1
No
Does cognitive behavior therapy improve depression symptoms, illness perception, and quality of life in patients with atrial fibrillation and depression?
Absolute Event Rate: 7.74% vs 5.59%
p-value: p=0.002
Cognitive behavioral therapy significantly improves depressive symptoms, illness perception, and the mental component of health-related quality of life in patients with atrial fibrillation and comorbid depression.
CBT improves HRQoL in depressed AF patients; extends evidence for psychological interventions in cardiac arrhythmia care.
Background AF Patients with depression resulted in a markedly reduced quality of life. The purpose of this study was to evaluate the efficacy of cognitive behavior therapy (CBT) on the health-related quality of life (HRQoL). Methods It was A longitudinal randomized controlled trial with a pre and 12-weeks post-test. Ninety persons were randomly assigned to either a CBT group (CBT) ( n = 45) or a treatment as usual (TAU) group ( n = 45). The outcome were changes in the HRQoL [12-item Short Form Health Survey, SF12, divided into two domains: the physical component summary (PCS) and the mental component summary (MCS)], changes in psychological distress [Hamilton Depression Rating Scale (HAM-D) and Patient Health Questionnaire-9 (PHQ-9)], and Illness Perception [Brief Illness Perception Questionnaire (BIPQ)]. Results There were statistically significant differences in score reduction for PHQ-9 (t = 3.186, P = 0.002), HAMD (t = 2.611, P = 0.011), BIPQ (t = 7.660, P < 0.001), and MCS (t = 4.301, P < 0.001) between CBT group and TAU group. Conclusions CBT improved HRQoL, Illness Perception and reduced Depressive symptoms in atrial fibrillation.
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Qu et al. (2022) conducted an RCT in Atrial Fibrillation with depression (n=90). Cognitive Behavior Therapy vs. Treatment as usual was evaluated on PHQ-9 score reduction (p=0.002). Cognitive behavior therapy significantly reduced PHQ-9 depression scores (mean reduction 7.74 vs 5.59, p=0.002) and improved mental health-related quality of life compared to treatment as usual in patients with atrial fibrillation.
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