Key result
All 9 cardiac troponin assays demonstrated good diagnostic performance for identifying NSTEMI (14% prevalence) when using the ESC algorithm based on variation between admission and 3 hours.
Why the study?
Do nine different cardiac troponin assays provide comparable diagnostic performance for NSTEMI in emergency department patients?
Observational (n=158)
Yes
Do nine different cardiac troponin assays provide comparable diagnostic performance for NSTEMI in emergency department patients?
Despite analytical heterogeneity, nine different cardiac troponin assays demonstrated comparable and good clinical diagnostic performance for NSTEMI when applying the standard ESC 0/3-hour algorithm.
Supports assay interchangeability with ESC 0/3-hour algorithm in ED; leaves open prospective validation across populations.
OBJECTIVES: We aimed to compare the use of nine different cardiac troponin (cTn) assays (2 cTnT and 7 cTnI) for the diagnosis of NSTEMI in a single multi-centre population. DESIGN AND METHODS: One hundred and fifty-eight patients were included (mean age 60 years, SD 17 years), including 23 patients (14%) with NSTEMI. RESULTS: The analytical comparison highlighted a large heterogeneity of cTn assays, as reflected by percentages of patients with detectable cTn, correlation coefficients, Passing-Bablok comparisons and concordance coefficients. Correlations within cTnI assays were good and correlation within cTnT assays was excellent. Diagnostic performances demonstrated that each cTn assay has specific threshold values. Furthermore, some assays (HS-cTnI and T, cTnI-Pathfast and cTnI-Centaur) indicated high sensitivity and negative predictive value using the limit of detection (LoD) diagnostic strategy. For the latter assays, a significant increase in specificity was found when using the 99th percentile or the H0-H3 strategies, in comparison to the LoD strategy. When applying the European Society of Cardiology H0-H3 algorithm, comparable diagnostic performances were obtained. CONCLUSION: All 9 cTn assays indicated overall good diagnostic performances for the diagnosis of NSTEMI in emergency departments when the recommended algorithm based on the variation of cTn value between two measurements at admission and 3 h later was used.
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Chenevier‐Gobeaux et al. (2018) conducted an observational in NSTEMI (n=158). Nine different cardiac troponin (cTn) assays was evaluated on Diagnosis of NSTEMI. All 9 cardiac troponin assays demonstrated good diagnostic performance for identifying NSTEMI (14% prevalence) when using the ESC algorithm based on variation between admission and 3 hours.
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