Key result
Colchicine administered before and after elective PCI did not significantly reduce myocardial injury, as assessed by mean changes in cardiac troponin I levels at 8 and 24 hours post-procedure.
Why the study?
Given the potential benefits of colchicine in coronary artery diseases, this study aimed to assess the impact of colchicine in preventing myocardial injury following elective PCI.
Does colchicine prevent myocardial injury in patients undergoing elective PCI?
RCT (n=102)
Single-blind
Online Graphpad prism randomization
No
Does colchicine prevent myocardial injury in patients undergoing elective PCI?
p-value: p=0.190
Administration of colchicine before and after elective PCI did not reduce periprocedural myocardial injury as measured by cardiac troponin I levels.
Colchicine does not prevent periprocedural myocardial injury; challenges prior suggestions and does not support routine pre-PCI use.
Purpose: Considering the potential benefits of colchicine in coronary artery diseases, we aimed to carry out the present study to assess the impact of colchicine in the prevention of myocardial injury following elective percutaneous coronary intervention (PCI). Methods: A randomized, single-blinded, clinical trial was carried out on 102 patients undergoing elective PCI. All patients received the standard treatment prior to performing PCI. Moreover, the intervention group received 1, 0.5, 0.5 mg colchicine 12 to 18 hours before, 30-60 min before, and 12 hours after PCI, respectively. Serum concentrations of cardiac troponin I (cTnI) were measured before, 8, and 24 hours after the procedure to assess myocardial damage during PCI. Results: There were no significant differences in cTnI levels at baseline (P = 0.839), 8 (P = 0.729), and 24 hours (P = 0.398) after PCI between the intervention and the control groups. Likewise, no significant differences were seen regarding the mean differences of cTnI at baseline and 8 hours (P =0.190), at baseline and 24 hours (P = 0.780), and 8 and 24 hours after PCI (P = 0.680) in both groups. Conclusion: The study did not support the potential benefit of colchicine in the prevention of myocardial injury following elective PCI. Conducting well-designed randomized clinical trials with adequate sample size is recommended.
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Aslanabadi et al. (2021) conducted an RCT in Ischemic heart disease (n=102). Colchicine vs. Standard treatment (no colchicine) was evaluated on Mean cTnI change from baseline at 8 and 24 hours after PCI (p=0.190). Colchicine administered before and after elective PCI did not significantly reduce myocardial injury, as assessed by mean changes in cardiac troponin I levels at 8 and 24 hours post-procedure.
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