Key result
Hypertension was the strongest independent risk factor for first stroke occurrence in Chinese individuals (RR 2.76), alongside old age, cardiovascular disease, and chronic kidney disease.
Why the study?
The study aimed to identify independent risk factors for the first occurrence of stroke in Chinese individuals.
What are the independent risk factors for the first occurrence of stroke in Chinese individuals?
Meta-Analysis (n=1,984,552)
What are the independent risk factors for the first occurrence of stroke in Chinese individuals?
Relative Risk: 2.76 (95% CI 2.26–3.37)
p-value: p=<0.001
Traditional risk factors such as hypertension, diabetes, and smoking, along with lifestyle factors, significantly increase the risk of first stroke in the Chinese population, emphasizing the need for targeted primary prevention.
Supports stroke risk stratification in Chinese adults; extends global data but remains hypothesis-generating pending trials.
This study aimed to identify independent risk factors for first occurrence of stroke in Chinese individuals based on prospective cohort studies. Forty prospective cohort studies assessing 1,984,552 individuals were selected for the final meta-analysis. The identified risk factors for stroke in the Chinese population included old age (RR = 1.86, 95%CI: 1.47-2.36), hypertension (RR = 2.76, 95%CI: 2.26-3.37), cardiovascular disease history (RR = 1.98, 95%CI: 1.06-3.69), chronic kidney disease (RR = 1.65, 95%CI: 1.36-2.01), diabetes mellitus (RR = 1.71, 95%CI: 1.34-2.18), metabolic syndrome (RR = 1.59, 95%CI: 1.33-1.90), hyperglycemia (RR = 1.49, 95% CI: 1.31-1.69), obesity (RR = 1.45, 95%CI: 1.29-1.63), smoking (RR = 1.42, 95% CI: 1.27-1.58), prolonged sleep time (> 7.5 h, RR = 1.44, 95%CI: 1.19-1.75), higher levels of triglyceride (RR = 1.19, 95%CI: 1.07-1.32), C-reactive protein (RR = 1.34, 95%CI: 1.07-1.69). High fruit-rich diet (RR = 0.68, 95%CI: 0.58-0.80) was associated with a lower risk of stroke. The spectrum and power of risk factors varied among different cohort inclusion years. These findings provide a comprehensive tool for the primary prevention of stroke in Chinese individuals.
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Yuan et al. (2022) conducted a meta-analysis in Stroke (n=1,984,552). Hypertension vs. Without hypertension was evaluated on First occurrence of stroke (RR 2.76, 95% CI 2.26-3.37, p=<0.001). Hypertension was the strongest independent risk factor for first stroke occurrence in Chinese individuals (RR 2.76), alongside old age, cardiovascular disease, and chronic kidney disease.
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