Does Hypoadiponectinemia Explain the Increased Risk of Diabetes and Cardiovascular Disease in South Asians?

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Key Points

To examine whether hypoadiponectinemia explains the elevated susceptibility to type 2 diabetes and cardiovascular disease in individuals of South Asian descent.
Reviewed observational and mechanistic evidence analyzing circulating adiponectin concentrations and cardiometabolic outcomes in South Asian populations.
Documented a disproportionately high burden of type 2 diabetes and cardiovascular disease among individuals of South Asian ancestry.
Identified low circulating adiponectin as a prominent candidate biomarker linked to insulin resistance and accelerated cardiovascular risk in this demographic.

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Hypoadiponectinemia may link excess cardiometabolic risk in South Asians; leaves open whether targeting it improves outcomes.

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Retnakaran et al. (2006) studied this question.

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