Unravelling the orientation of the inositol-biphosphate ring and its dependence on phosphatidylinositol 4,5-bisphosphate cluster formation in model membranes

This is the authors' abstract. We don't add key points for this paper.

HYPOTHESIS: Inositol phospholipids are well known to form clusters in the cytoplasmic leaflet of the plasma membrane that are responsible for the interaction and recruitment of proteins involved in key biological processes like endocytosis, ion channel activation and secondary messenger production. Although their phosphorylated inositol ring headgroup plays an important role in protein binding, its orientation with respect to the plane of the membrane and its lateral packing density has not been previously described experimentally. EXPERIMENTS: . FINDINGS: clusters with the change in orientation of the inositol-biphosphate headgroup, which was experimentally determined by neutron reflectometry.