In vitro study demonstrates selective fluorescent detection of thiols in living cells, suggesting robust utility for cellular redox bioimaging.
A new fluorescent turn-on probe (3) for the selective sensing and bioimaging of thiols is reported. In aqueous buffer solutions at physiological pH, thiols cleave the 2,4-dinitrobenzenesulfonyl group to release the red-emissive donor-acceptor fluorophore (4). The probe displays excellent immunity to interference from nitrogen and oxygen nucleophiles and the imaging of thiols in living cells is demonstrated.
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Bouffard et al. (2007) studied this question.
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