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June 1, 1988Journal of Biological ChemistryOpen Access

Multivalent control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mevalonate-derived product inhibits translation of mRNA and accelerates degradation of enzyme.

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Authors

MNMasahiko NakanishiOsaka University of Pharmaceutical SciencesJGJ L GoldsteinNational Institutes of HealthMBM S BrownHoward Hughes Medical Institute

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Cite This Study

Nakanishi et al. (1988) studied this question.

synapsesocial.com/papers/6a871ea2a6ddb97d43d3d2c2https://doi.org/10.1016/s0021-9258(18)68397-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sterols accelerate degradation of hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase encoded by a constitutively expressed cDNA.1985 · 127 citations
  2. 2Partial deletion of membrane-bound domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase eliminates sterol-enhanced degradation and prevents formation of crystalloid endoplasmic reticulum.1987 · 124 citations
  3. 3Lysosomes revisited1983 · 450 citations
  4. 4Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease1979 · 22,197 citations
  5. 5Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis by a non-sterol mevalonate-derived product in Mev-1 cells. Apparent translational control.1985 · 82 citations