Why the study?
Do first-onset drug-naïve patients with major depressive disorder and generalized anxiety disorder manifest different autonomic dysregulations measured by heart-rate variability?
Population
66 subjects including first-onset drug-naïve patients with major depressive disorder, generalized anxiety…
Comparison
Heart-rate variability and heart rate… vs Healthy controls
Design
Case-control
Authors
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HRV differences may aid early MDD-GAD differentiation; leaves open whether markers guide therapy or prognosis.
Do first-onset drug-naïve patients with major depressive disorder and generalized anxiety disorder manifest different autonomic dysregulations measured by heart-rate variability?
MDD and GAD exhibit distinct autonomic dysregulations in the early stages of illness, with MDD showing sympathetic activation and reduced reactivity, and GAD showing high parasympathetic tone.
Toshikazu Shinba (2016) studied this question.
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