Why the study?
The correlations between organ damage and hourly ambulatory blood pressure had not been established.
Is hourly morning ambulatory blood pressure associated with hypertensive organ damage in patients undergoing ambulatory BP monitoring?
Is hourly morning ambulatory blood pressure associated with hypertensive organ damage in patients undergoing ambulatory BP monitoring?
Morning ambulatory systolic blood pressure, particularly at 5 and 6 a.m., is independently associated with hypertensive organ damage such as increased left ventricular mass index and carotid intima-media thickness.
May refine organ damage assessment via hourly BP; leaves open clinical utility pending validation studies.
The correlations between organ damage and hourly ambulatory blood pressure (BP) have not been established. The patients were 1464 participants of the Japan Morning Surge-Home Blood Pressure (J-HOP) study participants who underwent ambulatory BP monitoring. The hourly systolic BP (SBP) at x o'clock was defined as the average of SBP values measured at times x - 30 minutes, x, and x + 30 minutes. The mean age was 64.8 ± 11.6 years. The percentage of male participants was 47.8%. The left ventricular mass index (LVMI) was significantly associated with SBP at 6 o'clock (r = 0.166, P < 0.001). The carotid intima-media thickness was significantly associated with SBP at 5 o'clock (r = 0.196, P < 0.001). After adjustment for age, sex, smoking, hyperlipidemia, diabetes mellitus, antihypertensive drug use, clinic SBP, and 24-hour ambulatory SBP, the correlations of the LVMI and hourly SBP at 6 o'clock remained significant (beta coefficient = 0.125, P < 0.01). In conclusion, morning ambulatory systolic BP especially at 5 and 6 o'clock was independently associated with organ damage.
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Wanthong et al. (2019) studied this question.
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