Lipid profiling analyses from mouse models and human infants

Figures

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  Figure 1. Suitable mouse strains for translational lipidomic experiments Illustration of the appropriate mouse strains to mimic human circulated lipoprotein profile that is dominated by VLDL/LDL particles. (A) Wildtype C57BL/6 is not appropriate since apolipoprotein B-containing particles (VLDL/LDL) in this strain are taken up by the liver and cleared from the circulation. (B and C) (B) Meanwhile, ApoE∗3Leiden (C) or Ldlr−/−. (D) Leiden mice (D) can be acceptable since their plasma lipids are confined to VLDL/LDL particles and levels can be increased with HFD. LDL=low-density lipoprotein, VLDL=very low-density lipoprotein, HFD=high-fat diets, WT=wild-type.

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  Figure 2. Obesogenic diets applicable for mice FFD=fast food diet, HFD=high-fat diet, WAT=white adipose tissue.

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  Figure 3. Lipid metabolism pathways