July 13, 2018Science ImmunologyOpen Access

MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage

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MHMelanie J. HarriffOregon Health & Science University CMCurtis McMurtreyPure Protein (United States)CFCara A. FroydUniversity of Chicago

Abstract

The identification, synthesis, and functional analysis of mycobacterial ligands reveal that MR1T ligands can be distinguished by MR1Ts with diverse TCR usage. These data demonstrate that MR1 can serve as an immune sensor of the microbial ligandome.

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Harriff et al. (2018) studied this question.

synapsesocial.com/papers/6a872918241d06231dbeeb4e https://doi.org/10.1126/sciimmunol.aao2556

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MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage

Abstract

Discussion

Member takes

Cite This Study

MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage

Abstract

Discussion

Member takes

Cite This Study

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