Why the study?
Does hyperoxia reduce superoxide radical generation and oxidative stress in a rat model of forebrain ischemia/reperfusion?
Population
28 male Wistar rats subjected to forebrain ischemia/reperfusion or sham procedures
Comparison
Hyperoxia vs Normoxia (reperfusion with FiO2 of 0.4)
Design
Preclinical
Follow-up
120 min after reperfusion
Authors
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Hyperoxia may reduce oxidative stress in cerebral ischemia models; hypothesis-generating and should not change practice.
Does hyperoxia reduce superoxide radical generation and oxidative stress in a rat model of forebrain ischemia/reperfusion?
Administration of 100% oxygen immediately after reperfusion suppresses oxidative stress and early inflammation in a rat model of cerebral ischemia/reperfusion.
Fujita et al. (2010) studied this question.
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