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Resistance topenicillin ingonococci isslowly but apparently steadily increasing inbothfrequency anddegree. Thedesirability ofeffective alternative treatment iswidelyrecognized, andtherapeutic studies havebeencarried outwithavariety ofother antibiotics withvarying butnever complete success. Resistance tosomeofthese, suchasstreptomycin andtetracycline, isknowntobecapable ofdevelopingless slowly thanthat topenicillin. Inthese circumstances itisnatural toturnto combinations ofanti-bacterial drugs fortworeasons: theyaresometimes moreeffective thaneither drug acting alone, andtheir simultaneous presence isa strong deterrent tothechange, whether adaptive or mutational, leading toincreased resistance toeither. Thispaperexamines themerits ofthree suchcombinations asdetermined bylaboratory methods. Combined action maybeoffourkinds, forwhich thefollowing terms anddefinitions areadopted here: (1)Indifferent Neither drugcontributes tothe action oftheother.
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Garrod et al. (1968) studied this question.
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