Answers are grounded in this paper and cite their sources.
We performed a comparative study of the detection of human cellular prions (PrP C ) with a quartz crystal microbalance (QCM) immunosensor using various antibodies against PrP C . The sensing layer was formed by immobilized antibodies on a surface of polyamidoamine dendrimers (PAMAM) of fourth generation (G4) with attached protein A. The sensitivity of detection depended on the kind of antibody used and the best detection limit was 0.8 nM. PrP C detection in 10 times diluted blood plasma revealed more complicated behavior of motional resistance, which is evidence on viscosity contribution. The sensor recovery was 82.2 %, suggesting certain matrix effects on prion detection.
No takes yet. Share an insight, caveat, or question.
Poturnayová et al. (2014) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: