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In vitro investigation demonstrates dose-dependent inhibition of oxidative burst and bacterial killing in human neutrophils by Legionella pneumophila toxin, indicating a novel immune evasion...
The effect of Legionella pneumophila toxin on selected functions of human polymorphonuclear leukocytes was investigated. Amounts of L. pneumophila toxin that had no effect on leukocyte viability or phagocytosis significantly decreased hexose monophosphate shunt activity and O2 consumption during phagocytosis and bacterial iodination and killing in a dose-dependent fashion. The mechanism of action of this toxin appears to be unique among bacterial products thus far studied.
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Friedman et al. (1982) studied this question.
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