OBJECTIVE: To determine the efficacy of intracavernosal injection of prostaglandin E1 (alprostadil) in elderly men with erectile failure. DESIGN: Prospective study. SETTING: Outpatients at a university-affiliated VA Medical Center. PARTICIPANTS: Ten subjects aged 65 years and older with duration of erectile failure of 6 months or longer. INTERVENTIONS: Subjects received intracavernosal injections of prostaglandin E1 in the office and self-administered intracavernosal prostaglandin E1 at home. MEASUREMENTS: Penile rigidity was measured by palpation and by the Rigiscan rigidity monitor. RESULTS: Intracavernosal injection of prostaglandin E1 produced erections adequate for intercourse in 9 of the 10 subjects. Attempts at intercourse were rated satisfactory by two-thirds of the subjects and their spouses. CONCLUSIONS: Intracavernosal injection of prostaglandin E1 is safe and effective for erectile failure in elderly men.
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Godschalk et al. (1994) studied this question.
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