Off-Pump Coronary Artery Bypass in Patients With Heparin-Induced Thrombocytopenia-Report of Two Cases-

2 male patients (ages 74 and 72) with type I heparin-induced thrombocytopenia (HIT) diagnosed after percutaneous coronary intervention for acute myocardial infarction, requiring off-pump coronary artery bypass (OPCAB).

Off-pump coronary artery bypass (OPCAB) using argatroban as an anticoagulant (Case 1: continuous infusion 5μg/kg/min; Case 2: bolus 10mg followed by continuous infusion 2μg/kg/min) to maintain ACT >200 seconds.

Postoperative complications (thrombocytopenia, bleeding, thrombosis) and overall postoperative course.safety