Key result
Cardiac surgery using argatroban and nafamostat mesilate was performed in a patient with HIT complicating VSP after AMI, though controlling the activated clotting time proved difficult.
Case Report (n=1)
No
Argatroban combined with nafamostat mesilate can enable cardiopulmonary bypass for urgent cardiac surgery in patients with HIT, though managing ACT and postoperative bleeding risk remains a significant challenge.
Case experience with argatroban and nafamostat in HIT-VSP post-AMI surgery highlights ACT control challenges; leaves open standardized protocols.
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Yoshioka et al. (2017) conducted a case report in Heparin-Induced Thrombocytopenia complicating Ventricular Septal Perforation after Acute Myocardial Infarction (n=1). Argatroban and nafamostat mesilate was evaluated on Successful surgical repair and activated clotting time (ACT) control. Cardiac surgery using argatroban and nafamostat mesilate was performed in a patient with HIT complicating VSP after AMI, though controlling the activated clotting time proved difficult.
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