This review addresses the controversy of whether mammalian cells use RNA interference as an antiviral innate immune response.
The question of whether any mammalian cells are able to mount an effective RNA interference-mediated antiviral innate immune response has remained highly controversial. In this Gem, I review recent data addressing this important issue and propose a testable hypothesis that can explain many of the apparently contradictory results published in this area of research.
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Bryan R. Cullen (2014) studied this question.
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