Why the study?
Does the quantitative thrombin time (QTT) accurately measure levels of recombinant hirudin and Hirulog in normal and abnormal plasma or whole blood?
Population
Normal and abnormal human plasmas and whole blood.
Comparison
Quantitative thrombin time (QTT) assay vs Expected values based on known added…
Design
Preclinical
Authors
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Supports QTT for monitoring direct thrombin inhibitors in abnormal plasmas; hypothesis-generating pending clinical validation.
Does the quantitative thrombin time (QTT) accurately measure levels of recombinant hirudin and Hirulog in normal and abnormal plasma or whole blood?
The quantitative thrombin time is a simple, rapid, and accurate in vitro method for monitoring recombinant hirudin and Hirulog levels, overcoming limitations of the aPTT in abnormal plasmas.
Reid et al. (1993) studied this question.
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